Endocrine Abstracts

Introduction: Hypothyroidism has been reported as an important factor in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) but studies about the relation between subclinical hypothyroidism and NAFLD have shown contradictory findings. The aim of this study was to conduct a systematic review and meta-analysis exploring the association between subclinical hypothyroidism and NAFLD.Methods: MEDLINE, EMBASE, Cochrane Library and sources for grey li...

Mycophenolate mofetil (MYC) is widely used in transplant medicine as an immunosuppressant drug to prevent rejection in organ transplantation. In this work we investigated the effect of MYC on the activity of androgen receptor (AR) by employing gene reporter assay (GRA) and PCR in prostate cancer cell line 22Rv1.Slight but significant activation of AR was observed for cells treated with MYC in stably transfected 22Rv1 cells (AIZ-AR). Moreover, significant...

Introduction: Palmitoleate, a proposed adipose tissue (AT)-derived lipokine, has been suggested to contribute to glucose homeostasis. However, data relating to the association between circulating palmitoleate and markers of insulin sensitivity in humans are equivocal. Recently, AT-derived fatty acid-hydroxy fatty acids (FAHFAs) have also been suggested to play a role in glucose homeostasis by increasing glucose uptake in AT. Again, data is conflicting for the association betwe...

Background: CYP24A1 gene encodes the enzyme vitamin D 24-hydroxylase, which converts active vitamin D to inactive metabolites. More than 20 currently described, usually biallelic pathogenic variants of this gene are responsible for idiopathic infantile hypercalcemia manifested typically in childhood (often in newborns) with hypercalcemia, hypercalciuria and nephrocalcinosis. However, a few patients (mostly with monoallelic heterozygous pathogenic variant) can develop mild symp...

Introduction: Adiponectin, adipocyte fatty acid-binding protein (A-FABP), fibroblast growth factor 21 (FGF-21), C1q/TNF-related protein 9 (CTRP9) and allograft inflammatory factor-1 (AIF-1) belong to the proteins produced by adipocyte tissue, which differently contribute to oxidative stress, chronic inflammation, insulin resistance and endothelial damage. The aim of this pilot study was to compare their levels in patients with diabetes and in healthy individuals and determine ...

Introduction: In the past 10 years, endoscopic resection of pituitary adenomas has become an alternative to microsurgical resection with the additional advantage of increasing the patient’s postoperative comfort. This analysis explored whether endoscopic resection can reduce the risk of postoperative neurohypophyseal dysfunction.Material and methods: We rated and compared the need to administer desmopressin during the first four postoperative days a...

The identification of genomic determinants responsible for common multifactorial diseases like type 2 diabetes mellitus (T2DM) is facilitated in large families from relatively genetically-isolated populations and can extend results from GWS based on a case–control cohort to detect rare alleles with strong effects. In order to search for sequence variants conferring risk of T2DM we previously conducted a genome-wide linkage study in 108 French–Canadian families from t...

Introduction: The shape of the glucose curve during oral glucose tolerance test (OGTT) reflects the dynamic of the glucose stimulus-response, and it can be considered as predictor of the impaired glucose tolerance and Type 2 Diabetes (T2D). Nucleoside diphosphate kinase 7, non-metastatic cells 7 (NME7) is an acknowledged member of ciliome and is involved in the biogenesis or function of cilia. Due to the fact that obesity and T2D are common in several ciliopathies, we enrolled...

Introduction: Congenital multiple pituitary hormone deficiency (MPHD) may result from defects of transcription factors that govern the early pituitary development. The most prevalent are two mutation of PROP1 gene: the c.296delGA and c.150delA.Methods: Seventy-five Lithuanian MPHD patients were tested for PROP1 defects. Perinatal and postnatal data were obtained from medical records. Hormonal investigations, pituitary imaging and GH the...